Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. Its role\nin the hepatocellular carcinoma (HCC) prognosis has not been investigated. In this study, we investigated whether TXNRD1\nfunctions as an independent prognostic factor for HCC patients.We found TXNRD1 was overexpressed in HCC tissues and cells,\nimmunohistochemical analysis suggested TXNRD1 was elevated in 57 of 120 (47.5%) clinical samples, and its level was increased\nwith the increasing clinical stage. In addition, TXNRD1 expression was positively correlated with clinical stage (
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